P-210: Evaluation of Anti-FSH Antibodies Levels as A Prognostic Marker in IVF Outcome

Background: The objective of this study is to establish importance of anti-FSH antibodies in IVF outcome. Materials and Methods: This research was designed based on evaluation of several articles from 2000 till 2012 about anti-FSH antibodies in IVF outcome. Results: Serum concentrations of anti-FSH IgG and IgA were linearly associated with poorer ovarian stimulation outcome. For example 1.0 AU difference in anti-FSH IgG was associated with a 220.6 IU increase in FSH needed for one embryo while the mean amount of FSH used per embryo was only 443.8 ± 401.2 IU.In fact, serum anti-FSH antibodies are associated with poor ovarian response to FSH stimulation in IVF. Based on Luborsky J et al. researches women who became pregnant had a lower frequency of anti-ovarian antibodies (AOA) than women who did not become pregnant. AOA positive patients often have antibodies against FSH. The follicular puncture performed in IVF procedure can induce the production of AOA. Conclusion: The success of attaining pregnancy following IVF depends on the effectiveness of controlled ovarian hyperstimulation (COH). Increased serum levels of anti-FSH IgG and IgA at the day of oocyte retrieval,were in linear association with poorer outcome of COH and with cut-off values > 1.0 AU predicting poor ovarian response (≤ 3 oocytes). For treatment before IVF procedures, Corticosteroid therapy was initiated in women who were positive for AOA by Western blot analysis or ELISA. So, anti-FSH antibodies could represent an important information about the matter of fertility assessment parameters such as age,ovarian volume, AFC and AMH to predict ovarian stimulation outcome.